Scientific output

Our publications in 2025

Alarcon Rios AC, Zwep LB, Vriesendorp B, et al. Colistin resistance dynamics in Pseudomonas aeruginosa under biofilm and planktonic growth. Antimicrob Agents Chemother. 2025 Oct. doi: 10. PMID: 40900213.
Bakker WA, Bertayli M, Dumas DB, et al. Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects. ACS Pharmacol Transl Sci. 2025 Feb 14. doi: 10. PMID: 40109754.
Bot L, van Mill JG, Smarius LJCA, et al. Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2025 Jul 24. doi: 10. PMID: 40705436.
Cnossen VM, Moreira PCL, Engelhardt OG, et al. Development of an intranasal, universal influenza vaccine in an EU-funded public-private partnership: the FLUniversal consortium. Front Immunol. 2025 May 23. doi: 10. PMID: 40486504.
de Bruin DT, Jansen MAA, Pereira DR, et al. POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo- controlled study. Front Immunol. 2026 Jan 23. doi: 10. PMID: 41660627.
de Cuba CMKE, de Goede AA, Klaassen ES, et al. TMS and EEG Pharmacodynamic Effects of a Selective Sphingosine-1-Phosphate Subtype 1 Receptor Agonist on Cortical Excitability in Healthy Subjects. Clin Pharmacol Ther. 2025 Mar. doi: 10. PMID: 39641417.
Dekkers N, Kruizinga MD, Dang H, et al. Physical recovery after local resection of nonpedunculated rectal adenomas and T1 carcinomas: endoscopic submucosal dissection versus transanal minimally invasive surgery. Gastrointest Endosc. 2025 Oct. doi: 10. PMID: 39956469.
Donker EM, van Rosse F, Janssen BJA, et al. Students' perspective on the Dutch National Pharmacotherapy Assessment, a national survey study among final-year medical students. Eur J Pharmacol. 2025 Feb 15. doi: 10. PMID: 39798917.
Donker EM, van Rosse F, Janssen BJA, et al. The impact of summative, formative or programmatic assessment on the Dutch National Pharmacotherapy assessment: A retrospective multicentre study. Eur J Pharmacol. 2025 Feb 15. doi: 10. PMID: 39798914.
Eveleens Maarse BC, Hofstede AD, Jansen MAA, et al. A systematic review of pharmaceutical targets in the mucosal immune system for treatment of non- intestinal auto-immune diseases. Biomed Pharmacother. 2025 Jul. doi: 10. PMID: 40446444.
Flores BN, Yu SB, Cohen IV, et al. Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial. Nat Commun. 2025 Aug 18. doi: 10. PMID: 40825784.
Gorbenko AA, de Cuba CMKE, de Goede AA, et al. Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3-Way Crossover Trial. Clin Pharmacol Ther. 2026 Jan. doi: 10. PMID: 40836528.
Gorbenko AA, Heuberger JAAC, Juachon M, et al. CB1 Receptor Antagonist Selonabant (ANEB-001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial. Clin Pharmacol Ther. 2025 May. doi: 10. PMID: 39898464.
Gorbenko AA, Post TE, Strugala PK, et al. Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study. . . doi: 10. PMID: 41398552.
Grievink HW, Breedveld C, Öhd J, et al. In vitro and in vivo lipopolysaccharide-driven activation of human neutrophils in healthy volunteers as a tool for clinical drug development. J Immunol Methods. 2025 Nov. doi: 10. PMID: 40865762.
Hepp DH, Ocran K, Szanto A, et al. Added value of a wrist-worn device for assessing tremor in Parkinson's disease: reliability and validity of tremor evaluation at home. NPJ Parkinsons Dis. 2025 Nov 20. doi: 10. PMID: 41266564.
Heuberger JAAC, de Jongh P, van Hoogdalem EJ, et al. Sentinel dosing: A proposed algorithm to guide decision making on which cohorts in early phase clinical pharmacology trials should use this approach. Br J Clin Pharmacol. 2025 Sep. doi: 10. PMID: 40370057.
Hoevenaars FPM, Scheithauer TPM, Eveleens Maarse BC, et al. Translating in vitro gut microbiota models to human context: compositional correlations under dietary fiber intervention. Front Microbiol. 2025 Dec 18. doi: 10. PMID: 41488312.
Hogenelst K, Krone T, Eveleens Maarse B, et al. A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study. Brain Behav Immun Health. 2024 Nov 28. doi: 10. PMID: 39717875.
Houvast RD, Sier VQ, van Duijvenvoorde M, et al. Correction: Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers. EJNMMI Res. 2025 Sep 2. doi: 10. PMID: 40892356.
Houvast RD, Sier VQ, van Duijvenvoorde M, et al. Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers. EJNMMI Res. 2025 Jun 6. doi: 10. PMID: 40478321.
Houvast RD, van Duijvenvoorde M, Thijse K, et al. Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation. Mol Diagn Ther. 2025 Mar. doi: 10. PMID: 39541080.
Jansen S, Olofsen E, Moss L, et al. Respiratory and antinociceptive effects of NOP-MOP agonist cebranopadol versus full opioid receptor agonist oxycodone: a comparison in healthy volunteers. . . doi: 10. PMID: 41379941.
Janus A, Dumas D, Le Douce J, et al. Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study. Neurol Ther. 2025 Feb. doi: 10. PMID: 39708220.
Kocatürk E, Chu DK, Türk M, et al. Management of Chronic Spontaneous Urticaria Made Practical: What Every Clinician Should Know. J Allergy Clin Immunol Pract. 2025 Sep. doi: 10. PMID: 40815254.
Kocatürk E, Salameh P, Asero R, et al. Sex matters in CSU: Women face greater burden and poorer urticaria control, especially in midlife-CURE insights. J Eur Acad Dermatol Venereol. 2026 Jan. doi: 10. PMID: 40965122.
Koopmans I, Doll RJ, Hagemeijer M, et al. The impact of a virtual wound on pain sensitivity: insights into the affective dimension of pain. Front Pain Res (Lausanne). 2025 Feb 26. doi: 10. PMID: 40078931.
Kuijpers KWK, Andersson K, Dahan A, et al. Opioid Detection Using Smartphone-Based Eye-Scanning. Sensors (Basel). 2025 Sep 3. doi: 10. PMID: 40942896.
Kuijpers KWK, Hämäläinen MD, Zetterström A, et al. Detecting benzodiazepine use through induced eye convergence inability with a smartphone app: a proof-of-concept study. Front Digit Health. 2025 May 30. doi: 10. PMID: 40520217.
Magliocca M, Koopmans I, Vaillant C, et al. Nighttime safety of daridorexant: Evaluation of responsiveness to an external noise stimulus, postural stability, walking, and cognitive function. J Psychopharmacol. 2025 Mar. doi: 10. PMID: 39641404.
Marek GJ, Makai-Bölöni S, Umbricht D, et al. A novel psychedelic 5-HT2A receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer. . . doi: 10. PMID: 41099491.
Meln I, Cnossen V, Corti N, et al. Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies - A stakeholder meeting report. Biologicals. 2025 May. doi: 10. PMID: 39824043.
Mieremet A, van der Wurff M, Pagan L, et al. Taxonomic and functional profiling of the vulvar microbiome indicates variations related to ecological signatures, aging, and health status. Front Microbiol. 2025 Sep 19. doi: 10. PMID: 41048510.
Mijnsbergen MD, Exadaktylos V, van Hilten JJ, et al. Disturbed rest-activity rhythm in Parkinson's disease: Associations with motor severity and orthostatic hypotension. J Parkinsons Dis. 2025 Dec. doi: 10. PMID: 41117495.
Nettesheim P, Vadodaria KC, Vanover KE, et al. Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies. Cells. 2025 Oct 10. doi: 10. PMID: 41148790.
Niesters M, Dahan A. Tolerant to Tolerance. Anesthesiology. 2025 Mar 1. doi: 10. PMID: 39932343.
Oliver M, Rousel J, Schoones JW, et al. Remote monitoring in chronic immune-mediated inflammatory diseases: A systematic review of active and passive approaches. JAAD Int. 2025 Dec 26. doi: 10. PMID: 41630872.
Otto ME, van der Heijden KV, Schoones JW, et al. Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis. Clin Pharmacokinet. 2025 Jan. doi: 10. PMID: 39812743.
Otto ME, van der Heijden KV, Schoones JW, et al. Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post‑Hoc Analysis. Clin Pharmacokinet. 2025 Mar. doi: 10. PMID: 39982684.
Peltenburg SI, van Nieuwenhuizen KE, Verweij EJT, et al. EUROPEAN ASSOCIATION OF PERINATAL MEDICINE Position statement: environmental sustainability in obstetric healthcare. Eur J Obstet Gynecol Reprod Biol. 2025 Jul. doi: 10. PMID: 40413886.
Petersen AB, Bredsdorff L, Tahir N, et al. Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge. Regul Toxicol Pharmacol. 2025 Sep. doi: 10. PMID: 40324560.
Post TE, De Gioannis R, Schmitz J, et al. Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia. J Pineal Res. 2025 Jan. doi: 10. PMID: 39821326.
Recourt K, Van Gerven J, Drenth N, et al. Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression. Front Neurosci. 2025 Feb 3. doi: 10. PMID: 39963257.
Ronner MN, De Kam ML, Van Reeuwijk S, et al. Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates. Front Pharmacol. 2026 Jan 2. doi: 10. PMID: 41552832.
Ronner MN, Grievink HW, Saghari M, et al. Profiling a Neo- Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double- Blind, Placebo-Controlled Study of the KLH Challenge Model. Clin Pharmacol Ther. 2025 Nov. doi: 10. PMID: 40696765.
Rousel J, Bergmans ME, Bruijnincx LJ, et al. Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo- controlled trial with guselkumab. Br J Clin Pharmacol. 2025 Dec. doi: 10. PMID: 40717537.
Ruijs TQ, de Cuba CMKE, Heuberger JAAC, et al. Safety, Pharmacokinetics, and Pharmacodynamics of a First-in- Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial. Clin Pharmacol Ther. 2025 Mar. doi: 10. PMID: 39651850.
Ryan K, Hooijmans CR, Struijs F, et al. A health-based recommended occupational exposure limit for isoflurane and sevoflurane using experimental animal data based on a systematic review and dose-response analysis. Environ Toxicol Pharmacol. 2026 Jan. doi: 10. PMID: 41453697.
Sessler DI, Ayad S, Bakal O, et al. Oliceridine for postoperative pain and opioid-related complications: The intravenous oliceridine and opioid-related complications (VOLITION) prospective cohort study. J Clin Anesth. 2025 Jul. doi: 10. PMID: 40446423.
Snoek MAJ, van Lemmen MA, van der Schrier R, et al. Recovery of the Acute Hypoxic Ventilatory Response after Reversal of a Minimal Neuromuscular Block: A Randomized Controlled Trial in Healthy, Nonobese Volunteers. Anesthesiology. 2025 Oct 1. doi: 10. PMID: 40644393.
Soegiharto R, Alizadeh Aghdam M, Sørensen JA, et al. Omalizumab is effective and safe in chronic inducible urticaria (CIndU): Real-world data from a large multi-national UCARE study. Allergy. 2025 Feb. doi: 10. PMID: 39377745.
Soegiharto R, Van der Wind E, Alizadeh Aghdam M, et al. Spectrum and Impact of Reported Side Effects of Omalizumab in Patients With Chronic Urticaria: A Long-Term Multicentre Real-World Study. Clin Exp Allergy. 2025 Jun. doi: 10. PMID: 40325793.
Stolz J, Salameh P, Asero R, et al. Parameters Linked With Higher Itch Severity in Chronic Spontaneous Urticaria-Chronic Urticaria Registry Results. J Allergy Clin Immunol Pract. 2025 Sep. doi: 10. PMID: 40447048.
Stuijt DG, Cnossen VM, Osman AFYSM, et al. Use of cimetidine to enhance systemic acyclovir concentrations in patients with ineffective suppressive therapy for recurring herpes simplex virus infections: A novel purpose for an old drug. . . doi: 10. PMID: 41063629.
Stuijt DG, Kos M, Dingemans I, et al. Perspectives, willingness, and current use of mobile health (mHealth) by patients with cancer for remote monitoring during cancer treatment: a Dutch national cross-sectional survey. ESMO Real World Data Digit Oncol. 2025 Feb 17. doi: 10. PMID: 41647351.
van den Noort JA, Assil S, Ronner MN, et al. Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development. Inflammation. 2025 Jun. doi: 10. PMID: 39183259.
van den Noort JA, Meijs AC, Klarenbeek NB, et al. Navigating adverse immunostimulation: A practical guide for clinical researchers. . . doi: 10. PMID: 40944335.
van den Noort JA, van Ruissen MCE, Smidt LCA, et al. Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience. . . doi: 10. PMID: 40969149.
van der Heijden KV, Otto ME, Schoones JW, et al. Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis. Clin Pharmacokinet. 2025 Feb. doi: 10. PMID: 39838235.
van der Heijden KV, Zuiker RGJA, Otto ME, et al. Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Transl Sci. 2025 May. doi: 10. PMID: 40356576.
van der Sluijs PJ, Safai Pour K, Berends CL, et al. Clonazepam repurposing in ARID1B patients through conventional RCT and N-of-1 trials: an experimental strategy for orphan disease development. J Med Genet. 2025 Feb 26. doi: 10. PMID: 39740803.
van Kraaij SJW, Eveleens Maarse BC, Hoevenaars FPM, et al. Microvascular effects of a mixed meal tolerance test: a model validation study. Clin Physiol Funct Imaging. 2025 Jan. doi: 10. PMID: 39308427.
van Lemmen M, Olofsen E, van Velzen M, et al. Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic-Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression. Anesthesiology. 2025 Nov 1. doi: 10. PMID: 40773676.
van Lemmen MA, van Velzen M, Sarton EY, et al. A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. Nat Commun. 2025 May 19. doi: 10. PMID: 40389500.
van Ruissen MCE, van Diemen M, Botros L, et al. Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers. Clin Pharmacol Ther. 2026 Mar. doi: 10. PMID: 41240016.
van Ruissen MCE, van Kraaij SJW, Wolfova J, et al. Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male Participants. Clin Transl Sci. 2025 Aug. doi: 10. PMID: 40711888.
van Velze VY, Burger HL, van der Steenhoven TJ, et al. Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study. JMIR Med Inform. 2025 Oct 10. doi: 10. PMID: 41072008.
Voorde WT, Wind S, Abdisalaam I, et al. A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers. Eur J Pharm Sci. 2025 Jan 1. doi: 10. PMID: 39084539.
Warmerdam MI, Creemers DMJ, Kusters M, et al. Long-term Local Control Following CEA-targeted Fluorescence-guided Surgery in Patients With Locally Advanced and Recurrent Rectal Cancer. Mol Imaging Biol. 2025 Aug. doi: 10. PMID: 40471424.
Wilschut ED, de Winter EP, Bos EJ, et al. Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial. . . doi: 10. PMID: 40751286.
Zonoobi E, Neijenhuis LKA, Lemij AA, et al. Impact of Neoadjuvant Treatment on Target Expression in Rectal Cancer for Near-Infrared Tumor Imaging. Cancers (Basel). 2025 Jun 12. doi: 10. PMID: 40563608.

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